Drug interactions
Acetylsalicylic acid + Oxacillin
Severity: Minor
Acetylsalicylic acid and Oxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can compete with penicillins for protein binding and renal tubular secretion, which could theoretically raise penicillin levels. The clinical impact is small and rarely requires action.
What this interaction means in plain words
Acetylsalicylic acid and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Oxacillin belongs to Anti Bacterial.
Why it happens
Competition for plasma protein binding and renal tubular secretion by organic anion transporters.
What to do
No routine adjustment needed; be alert for increased penicillin adverse effects when high-dose aspirin is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Oxacillin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Oxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can compete with penicillins for protein binding and renal tubular secretion, which could theoretically raise penicillin levels. The clinical impact is small and rarely requires action.
How serious is the interaction between Acetylsalicylic acid and Oxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; be alert for increased penicillin adverse effects when high-dose aspirin is used.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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