Drug interactions
Cholera vaccine + Oxacillin
Severity: Moderate
Cholera vaccine and Oxacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
What this interaction means in plain words
Cholera vaccine and Oxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces replication and immunogenicity.
What to do
Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
- Minocycline + Oxacillin Moderate
Frequently asked questions
Can I take Cholera vaccine with Oxacillin?
MediHelp rates the interaction as moderate. Cholera vaccine and Oxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
How serious is the interaction between Cholera vaccine and Oxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Demeclocycline. The full list is on the Oxacillin page.
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