Drug interactions
Acetylsalicylic acid + Paroxetine
Severity: Moderate
Acetylsalicylic acid and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking an SSRI with aspirin raises the risk of bleeding, especially from the upper gastrointestinal tract. The two drugs affect platelet function through different routes and their effects add together.
What this interaction means in plain words
Acetylsalicylic acid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation, while aspirin irreversibly inhibits platelet COX-1 and can injure gastric mucosa, producing additive bleeding risk.
What to do
Assess GI bleeding risk and consider adding a proton pump inhibitor in higher-risk patients. Advise patients to report black stools, hematemesis or unusual bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Paroxetine?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking an SSRI with aspirin raises the risk of bleeding, especially from the upper gastrointestinal tract. The two drugs affect platelet function through different routes and their effects add together.
How serious is the interaction between Acetylsalicylic acid and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess GI bleeding risk and consider adding a proton pump inhibitor in higher-risk patients. Advise patients to report black stools, hematemesis or unusual bruising.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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