Drug interactions
Paroxetine + Procarbazine
Severity: Contraindicated
Paroxetine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and combining it with paroxetine raises the risk of serotonin syndrome or hypertensive reactions. The evidence is largely mechanistic and from MAOI class labeling.
What this interaction means in plain words
Paroxetine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Paroxetine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Procarbazine's MAO inhibition adds to paroxetine's serotonin reuptake blockade, increasing synaptic serotonin.
What to do
Avoid concurrent use and keep at least 14 days between stopping procarbazine and starting paroxetine. Choose a non-serotonergic option for depression during procarbazine therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Selegiline Contraindicated
- Paroxetine + Selegiline transdermal Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Paroxetine with Procarbazine?
MediHelp rates the interaction as contraindicated. Paroxetine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has weak MAO-inhibiting activity, and combining it with paroxetine raises the risk of serotonin syndrome or hypertensive reactions. The evidence is largely mechanistic and from MAOI class labeling.
How serious is the interaction between Paroxetine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep at least 14 days between stopping procarbazine and starting paroxetine. Choose a non-serotonergic option for depression during procarbazine therapy.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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