Drug interactions
Acetylsalicylic acid + Sacubitril / valsartan
Severity: Moderate
Acetylsalicylic acid and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses, aspirin can reduce renal prostaglandin synthesis, which may worsen renal function and blunt the antihypertensive effect of sacubitril/valsartan. Risk is greatest in elderly, volume-depleted or renally impaired patients, and hyperkalemia may also occur. Low-dose aspirin carries much less risk.
What this interaction means in plain words
Acetylsalicylic acid and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Loss of prostaglandin-mediated afferent arteriolar dilation with simultaneous angiotensin receptor blockade reduces glomerular filtration and promotes sodium retention and hyperkalemia.
What to do
Monitor renal function, serum potassium and blood pressure when higher-dose aspirin is used; ensure adequate hydration and prefer low-dose aspirin where indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Frequently asked questions
Can I take Acetylsalicylic acid with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses, aspirin can reduce renal prostaglandin synthesis, which may worsen renal function and blunt the antihypertensive effect of sacubitril/valsartan. Risk is greatest in elderly, volume-depleted or renally impaired patients, and hyperkalemia may also occur. Low-dose aspirin carries much less risk.
How serious is the interaction between Acetylsalicylic acid and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, serum potassium and blood pressure when higher-dose aspirin is used; ensure adequate hydration and prefer low-dose aspirin where indicated.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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