Drug interactions
Aspirin + Telmisartan-amlodipine
Severity: Moderate
Aspirin and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses aspirin can blunt the antihypertensive effect of telmisartan and impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has little effect.
What this interaction means in plain words
Aspirin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion and promotes sodium retention in combination with angiotensin receptor blockade.
What to do
Low-dose aspirin needs no change; with analgesic doses monitor blood pressure, creatinine and potassium and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Aspirin with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Aspirin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses aspirin can blunt the antihypertensive effect of telmisartan and impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has little effect.
How serious is the interaction between Aspirin and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Low-dose aspirin needs no change; with analgesic doses monitor blood pressure, creatinine and potassium and maintain hydration.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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