Drug interactions
Acetylsalicylic acid + Timolol
Severity: Minor
Acetylsalicylic acid and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular anti-inflammatory doses of aspirin may blunt the antihypertensive effect of oral timolol. Low-dose aspirin is unlikely to matter clinically.
What this interaction means in plain words
Acetylsalicylic acid and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandins and renal sodium and water retention oppose the antihypertensive action.
What to do
Monitor blood pressure if high-dose aspirin is used for more than a few days. No change is needed with low-dose aspirin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Acetylsalicylic acid with Timolol?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regular anti-inflammatory doses of aspirin may blunt the antihypertensive effect of oral timolol. Low-dose aspirin is unlikely to matter clinically.
How serious is the interaction between Acetylsalicylic acid and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if high-dose aspirin is used for more than a few days. No change is needed with low-dose aspirin.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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