Drug interactions
Amiodarone + Timolol
Severity: Major
Amiodarone and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
What this interaction means in plain words
Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects, plus CYP2D6 inhibition by amiodarone reducing timolol clearance.
What to do
Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Timolol?
MediHelp rates the interaction as major. Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
How serious is the interaction between Amiodarone and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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