Drug interactions
Acetylsalicylic acid + Tirofiban
Severity: Major
Acetylsalicylic acid and Tirofiban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin with tirofiban increases the risk of bleeding. The combination is used deliberately in acute coronary syndromes and PCI but needs close observation.
What this interaction means in plain words
Acetylsalicylic acid and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Tirofiban belongs to Cardiovascular.
Why it happens
Aspirin inhibits thromboxane-dependent platelet activation while tirofiban blocks glycoprotein IIb/IIIa receptors, giving additive antiplatelet effect.
What to do
Use only for a clear indication and monitor for bleeding, hemoglobin and platelet count. Minimize invasive procedures and vascular access trauma.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Tirofiban, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Tirofiban
Frequently asked questions
Can I take Acetylsalicylic acid with Tirofiban?
MediHelp rates the interaction as major. Acetylsalicylic acid and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aspirin with tirofiban increases the risk of bleeding. The combination is used deliberately in acute coronary syndromes and PCI but needs close observation.
How serious is the interaction between Acetylsalicylic acid and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only for a clear indication and monitor for bleeding, hemoglobin and platelet count. Minimize invasive procedures and vascular access trauma.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
