Drug interactions
Acetylsalicylic acid + Tobramycin
Severity: Moderate
Acetylsalicylic acid and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates may reduce renal clearance of aminoglycosides and can themselves be ototoxic. Higher tobramycin levels may increase nephrotoxicity and hearing and balance toxicity, especially in neonates or renal impairment.
What this interaction means in plain words
Acetylsalicylic acid and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
Reduced renal elimination of tobramycin plus additive ototoxicity and nephrotoxicity.
What to do
Monitor tobramycin trough levels, renal function and auditory symptoms. Avoid high-dose aspirin where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Tobramycin?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates may reduce renal clearance of aminoglycosides and can themselves be ototoxic. Higher tobramycin levels may increase nephrotoxicity and hearing and balance toxicity, especially in neonates or renal impairment.
How serious is the interaction between Acetylsalicylic acid and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin trough levels, renal function and auditory symptoms. Avoid high-dose aspirin where alternatives exist.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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