Drug interactions
Acetylsalicylic acid + Tolmetin
Severity: Moderate
Acetylsalicylic acid and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using aspirin together with tolmetin increases the risk of gastrointestinal ulceration and bleeding without added therapeutic benefit. Tolmetin may also blunt the antiplatelet effect of low-dose aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive inhibition of platelet function and gastric prostaglandin synthesis, with possible competition at platelet COX-1.
What to do
Avoid the combination where possible; if both are needed, add a proton pump inhibitor and monitor for GI bleeding. Time low-dose aspirin before the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Tolmetin?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using aspirin together with tolmetin increases the risk of gastrointestinal ulceration and bleeding without added therapeutic benefit. Tolmetin may also blunt the antiplatelet effect of low-dose aspirin.
How serious is the interaction between Acetylsalicylic acid and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are needed, add a proton pump inhibitor and monitor for GI bleeding. Time low-dose aspirin before the NSAID.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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