Drug interactions
Ketorolac intranasal + Tolmetin
Severity: Contraindicated
Ketorolac intranasal and Tolmetin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent tolmetin and intranasal ketorolac provides no added benefit and increases the likelihood of gastrointestinal bleeding, renal dysfunction and cardiovascular events. Ketorolac is labeled to be avoided with other NSAIDs.
What this interaction means in plain words
Ketorolac intranasal and Tolmetin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Avoid the combination and use a single NSAID. Add paracetamol or another non-NSAID if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tolmetin
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
- Apixaban + Tolmetin Major
Frequently asked questions
Can I take Ketorolac intranasal with Tolmetin?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Tolmetin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent tolmetin and intranasal ketorolac provides no added benefit and increases the likelihood of gastrointestinal bleeding, renal dysfunction and cardiovascular events. Ketorolac is labeled to be avoided with other NSAIDs.
How serious is the interaction between Ketorolac intranasal and Tolmetin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single NSAID. Add paracetamol or another non-NSAID if needed.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Tolmetin page.
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