Drug interactions
Acetylsalicylic acid + Triamterene
Severity: Moderate
Acetylsalicylic acid and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic that can cause hyperkalemia, and NSAID-type effects of higher-dose aspirin can reduce renal function and potassium excretion. Aspirin may also blunt the diuretic effect, and acute kidney injury has been reported with triamterene and NSAIDs.
What this interaction means in plain words
Acetylsalicylic acid and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
Aspirin-mediated inhibition of renal prostaglandins reduces renal perfusion and potassium excretion, compounding triamterene's potassium retention.
What to do
Monitor serum potassium and renal function when higher-dose aspirin is used with triamterene. Low-dose aspirin generally needs only routine monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Acetylsalicylic acid with Triamterene?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene is a potassium-sparing diuretic that can cause hyperkalemia, and NSAID-type effects of higher-dose aspirin can reduce renal function and potassium excretion. Aspirin may also blunt the diuretic effect, and acute kidney injury has been reported with triamterene and NSAIDs.
How serious is the interaction between Acetylsalicylic acid and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when higher-dose aspirin is used with triamterene. Low-dose aspirin generally needs only routine monitoring.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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