Drug interactions
Aspirin / citric acid / sodium bicarbonate + Captopril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic doses can reduce the antihypertensive effect of captopril and may impair renal function, particularly in elderly or volume-depleted patients. The effect is generally minor with occasional low-dose aspirin but more relevant with regular high doses. The sodium load from the bicarbonate component may also counter blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by aspirin reduces ACE inhibitor efficacy and glomerular perfusion.
What to do
Avoid regular use of high-dose effervescent aspirin; monitor blood pressure and serum creatinine if needed. Prefer paracetamol for analgesia where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Captopril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at analgesic doses can reduce the antihypertensive effect of captopril and may impair renal function, particularly in elderly or volume-depleted patients. The effect is generally minor with occasional low-dose aspirin but more relevant with regular high doses. The sodium load from the bicarbonate component may also counter blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of high-dose effervescent aspirin; monitor blood pressure and serum creatinine if needed. Prefer paracetamol for analgesia where possible.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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