Drug interactions
Aspirin / citric acid / sodium bicarbonate + Enalapril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic-dose aspirin can inhibit renal prostaglandin synthesis, which may blunt enalapril's antihypertensive effect and impair kidney function, particularly in elderly or volume-depleted patients. Low-dose aspirin has less effect. The sodium bicarbonate content adds a sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition by aspirin reduces renal vasodilation and sodium excretion, opposing ACE inhibitor effects.
What to do
Avoid regular high-dose use; monitor blood pressure and renal function, and ensure hydration if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Enalapril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic-dose aspirin can inhibit renal prostaglandin synthesis, which may blunt enalapril's antihypertensive effect and impair kidney function, particularly in elderly or volume-depleted patients. Low-dose aspirin has less effect. The sodium bicarbonate content adds a sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular high-dose use; monitor blood pressure and renal function, and ensure hydration if used.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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