Drug interactions
Aspirin / citric acid / sodium bicarbonate + Escitalopram
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent aspirin product delivers analgesic-dose aspirin, which combined with escitalopram increases the risk of gastrointestinal and other bleeding. The sodium bicarbonate does not offset the antiplatelet effect.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Platelet serotonin depletion by the SSRI plus COX-1 inhibition by aspirin and mucosal injury.
What to do
Limit use to short courses and consider an alternative analgesic such as paracetamol. Monitor for melena and anemia, adding gastroprotection in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Escitalopram?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This effervescent aspirin product delivers analgesic-dose aspirin, which combined with escitalopram increases the risk of gastrointestinal and other bleeding. The sodium bicarbonate does not offset the antiplatelet effect.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses and consider an alternative analgesic such as paracetamol. Monitor for melena and anemia, adding gastroprotection in at-risk patients.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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