Drug interactions
Aspirin / citric acid / sodium bicarbonate + Fenoprofen
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking fenoprofen with an aspirin-containing effervescent product increases the likelihood of gastric injury and bleeding. Aspirin's irreversible platelet inhibition adds to the NSAID's reversible effect, and fenoprofen may reduce aspirin's antiplatelet benefit. Combined salicylate and NSAID exposure also adds to renal risk.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive COX inhibition with platelet dysfunction and mucosal prostaglandin depletion, plus competition at platelet COX-1.
What to do
Avoid concurrent use unless aspirin is needed for cardiovascular protection; then add gastroprotection and monitor for GI bleeding and renal function. The sodium load of effervescent products should be considered in hypertension or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Fenoprofen?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking fenoprofen with an aspirin-containing effervescent product increases the likelihood of gastric injury and bleeding. Aspirin's irreversible platelet inhibition adds to the NSAID's reversible effect, and fenoprofen may reduce aspirin's antiplatelet benefit. Combined salicylate and NSAID exposure also adds to renal risk.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless aspirin is needed for cardiovascular protection; then add gastroprotection and monitor for GI bleeding and renal function. The sodium load of effervescent products should be considered in hypertension or heart failure.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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