Drug interactions
Aspirin / citric acid / sodium bicarbonate + Ginko biloba
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Ginko biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo extracts may inhibit platelet-activating factor and platelet function, and aspirin irreversibly inhibits platelet aggregation. Taken together they may raise the risk of bruising and bleeding, including rare intracranial or ocular bleeds.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: ginkgo antagonizes platelet-activating factor while aspirin irreversibly inhibits COX-1.
What to do
Ask patients about ginkgo use and advise against it when aspirin is taken regularly, particularly at higher doses or alongside other antithrombotics. Monitor for bleeding and stop ginkgo before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginko biloba
- Ginko biloba + Ketorolac Major
- Abciximab + Ginko biloba Moderate
- Aceclofenac + Ginko biloba Moderate
- Acemetacin + Ginko biloba Moderate
- Alteplase + Ginko biloba Moderate
- Anagrelide + Ginko biloba Moderate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Ginko biloba?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Ginko biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo extracts may inhibit platelet-activating factor and platelet function, and aspirin irreversibly inhibits platelet aggregation. Taken together they may raise the risk of bruising and bleeding, including rare intracranial or ocular bleeds.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Ginko biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about ginkgo use and advise against it when aspirin is taken regularly, particularly at higher doses or alongside other antithrombotics. Monitor for bleeding and stop ginkgo before surgery.
What other medicines interact with Ginko biloba?
MediHelp also lists interactions of Ginko biloba with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Ginko biloba page.
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