Drug interactions
Aspirin / citric acid / sodium bicarbonate + Hydrochlorothiazide-olmesartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is usually given at analgesic doses, which can blunt the antihypertensive and diuretic action of olmesartan and hydrochlorothiazide and reduce renal function in volume-depleted or older patients. The sodium bicarbonate also adds a sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, opposing ARB and diuretic effects; the sodium load adds to fluid retention.
What to do
Limit use to short courses and monitor blood pressure, creatinine and potassium. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is usually given at analgesic doses, which can blunt the antihypertensive and diuretic action of olmesartan and hydrochlorothiazide and reduce renal function in volume-depleted or older patients. The sodium bicarbonate also adds a sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses and monitor blood pressure, creatinine and potassium. Ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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