Drug interactions
Aspirin / citric acid / sodium bicarbonate + Lithium
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The sodium bicarbonate in this effervescent product can increase urinary lithium excretion and lower serum lithium. The sodium load and large dose of aspirin are additional considerations.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sodium bicarbonate alkalinizes urine and adds a sodium load that increases renal lithium clearance; aspirin itself has little effect.
What to do
Monitor serum lithium if the product is used regularly, especially at the start or end of therapy. Adjust the lithium dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Lithium?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The sodium bicarbonate in this effervescent product can increase urinary lithium excretion and lower serum lithium. The sodium load and large dose of aspirin are additional considerations.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum lithium if the product is used regularly, especially at the start or end of therapy. Adjust the lithium dose according to levels.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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