Drug interactions
Aspirin / citric acid / sodium bicarbonate + Olmesartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The effervescent product delivers analgesic-dose aspirin, which can blunt olmesartan's effect and worsen renal function in volume-depleted or older patients. The sodium load may also work against blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, and the sodium content adds fluid retention, opposing ARB therapy.
What to do
Limit use to short courses, ensure hydration, and monitor blood pressure and creatinine. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Olmesartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The effervescent product delivers analgesic-dose aspirin, which can blunt olmesartan's effect and worsen renal function in volume-depleted or older patients. The sodium load may also work against blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses, ensure hydration, and monitor blood pressure and creatinine. Consider paracetamol as an alternative.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
