Drug interactions
Aspirin / citric acid / sodium bicarbonate + Perindopril
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic-dose aspirin can blunt the antihypertensive effect of ACE inhibitors and may worsen renal function, particularly in older or volume-depleted patients. Effervescent products also contain a notable sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis by aspirin reduces renal perfusion and antagonises ACE inhibitor effect; sodium load adds to this.
What to do
Avoid regular high-dose use of aspirin-containing effervescent products with perindopril. Monitor blood pressure and renal function if use is prolonged, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Perindopril?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic-dose aspirin can blunt the antihypertensive effect of ACE inhibitors and may worsen renal function, particularly in older or volume-depleted patients. Effervescent products also contain a notable sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular high-dose use of aspirin-containing effervescent products with perindopril. Monitor blood pressure and renal function if use is prolonged, and ensure adequate hydration.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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