Drug interactions
Aspirin rectal + Captopril
Severity: Moderate
Aspirin rectal and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses can reduce the antihypertensive effect of ACE inhibitors and impair renal function. Risk is greatest in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Aspirin rectal and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and opposes ACE inhibitor-mediated vasodilation.
What to do
Monitor blood pressure, creatinine and potassium with repeated or high-dose use and keep patients well hydrated. Use the lowest effective aspirin dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Aspirin rectal with Captopril?
MediHelp rates the interaction as moderate. Aspirin rectal and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at analgesic doses can reduce the antihypertensive effect of ACE inhibitors and impair renal function. Risk is greatest in older, dehydrated or renally impaired patients.
How serious is the interaction between Aspirin rectal and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with repeated or high-dose use and keep patients well hydrated. Use the lowest effective aspirin dose for the shortest time.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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