Drug interactions
Aspirin rectal + Citalopram
Severity: Moderate
Aspirin rectal and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed and still inhibits platelets, while citalopram impairs platelet serotonin uptake. Bleeding risk is increased, including gastrointestinal bleeding.
What this interaction means in plain words
Aspirin rectal and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet inhibition from SSRI serotonin depletion and aspirin COX-1 inhibition.
What to do
Use only when clearly indicated and monitor for bleeding or anemia. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Citalopram?
MediHelp rates the interaction as moderate. Aspirin rectal and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is systemically absorbed and still inhibits platelets, while citalopram impairs platelet serotonin uptake. Bleeding risk is increased, including gastrointestinal bleeding.
How serious is the interaction between Aspirin rectal and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when clearly indicated and monitor for bleeding or anemia. Consider gastroprotection in high-risk patients.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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