Drug interactions
Aspirin rectal + Enalapril
Severity: Moderate
Aspirin rectal and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin can reduce the blood pressure lowering effect of enalapril and, at higher doses, impair renal function in vulnerable patients. The effect is dose related and is minor with low-dose aspirin.
What this interaction means in plain words
Aspirin rectal and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis by aspirin reduces vasodilation and sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure and serum creatinine and potassium if repeated or high doses of rectal aspirin are used. Avoid prolonged use in dehydrated or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Aspirin rectal with Enalapril?
MediHelp rates the interaction as moderate. Aspirin rectal and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin can reduce the blood pressure lowering effect of enalapril and, at higher doses, impair renal function in vulnerable patients. The effect is dose related and is minor with low-dose aspirin.
How serious is the interaction between Aspirin rectal and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium if repeated or high doses of rectal aspirin are used. Avoid prolonged use in dehydrated or renally impaired patients.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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