Drug interactions
Aspirin rectal + Escitalopram
Severity: Moderate
Aspirin rectal and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and retains its antiplatelet effect, so with escitalopram bleeding risk is increased, though direct gastric irritation may be less.
What this interaction means in plain words
Aspirin rectal and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Platelet serotonin depletion by the SSRI plus COX-1 inhibition by systemically absorbed aspirin.
What to do
Monitor for bleeding signs and anemia, and consider gastroprotection in high-risk patients. Use the lowest effective aspirin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Escitalopram?
MediHelp rates the interaction as moderate. Aspirin rectal and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and retains its antiplatelet effect, so with escitalopram bleeding risk is increased, though direct gastric irritation may be less.
How serious is the interaction between Aspirin rectal and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and anemia, and consider gastroprotection in high-risk patients. Use the lowest effective aspirin dose.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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