Drug interactions
Aspirin rectal + Fenoprofen
Severity: Moderate
Aspirin rectal and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with aspirin raises the risk of gastrointestinal ulceration and bleeding because both impair platelet function and damage the gastric mucosa. Fenoprofen may also compete with aspirin at platelet COX-1 and blunt aspirin's antiplatelet cardioprotection. Both drugs can impair renal function and fluid handling.
What this interaction means in plain words
Aspirin rectal and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive COX inhibition causes platelet dysfunction and loss of mucosal prostaglandin protection, and fenoprofen may interfere with aspirin binding to platelet COX-1.
What to do
Avoid routine co-use; if aspirin is taken for cardioprotection, consider a gastroprotective agent and monitor for GI bleeding and renal function. Choose a different analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Aspirin rectal with Fenoprofen?
MediHelp rates the interaction as moderate. Aspirin rectal and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with aspirin raises the risk of gastrointestinal ulceration and bleeding because both impair platelet function and damage the gastric mucosa. Fenoprofen may also compete with aspirin at platelet COX-1 and blunt aspirin's antiplatelet cardioprotection. Both drugs can impair renal function and fluid handling.
How serious is the interaction between Aspirin rectal and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use; if aspirin is taken for cardioprotection, consider a gastroprotective agent and monitor for GI bleeding and renal function. Choose a different analgesic where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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