Drug interactions
Aspirin rectal + Glibenclamide
Severity: Moderate
Aspirin rectal and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at higher doses can add to the glucose-lowering effect of glyburide. Hypoglycemia is possible with sustained salicylate dosing.
What this interaction means in plain words
Aspirin rectal and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates increase insulin secretion, reduce glucose production, and may displace sulfonylureas from protein binding.
What to do
Monitor blood glucose during repeated or high-dose use and reduce glyburide if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Aspirin rectal with Glibenclamide?
MediHelp rates the interaction as moderate. Aspirin rectal and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at higher doses can add to the glucose-lowering effect of glyburide. Hypoglycemia is possible with sustained salicylate dosing.
How serious is the interaction between Aspirin rectal and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during repeated or high-dose use and reduce glyburide if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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