Drug interactions
Aspirin rectal + Hydrochlorothiazide-olmesartan
Severity: Moderate
Aspirin rectal and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin behaves like oral aspirin; at higher doses it can blunt the effects of olmesartan and hydrochlorothiazide and contribute to renal impairment in volume-depleted patients. Low doses have little effect.
What this interaction means in plain words
Aspirin rectal and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing ARB and diuretic effects.
What to do
Monitor blood pressure, renal function and potassium if analgesic-dose aspirin is used regularly. Prefer low-dose aspirin where antiplatelet effect is the goal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Aspirin rectal with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin behaves like oral aspirin; at higher doses it can blunt the effects of olmesartan and hydrochlorothiazide and contribute to renal impairment in volume-depleted patients. Low doses have little effect.
How serious is the interaction between Aspirin rectal and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if analgesic-dose aspirin is used regularly. Prefer low-dose aspirin where antiplatelet effect is the goal.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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