Drug interactions
Aspirin rectal + Lithium
Severity: Minor
Aspirin rectal and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin generally has little effect on serum lithium levels, so a meaningful interaction is unlikely. High doses could theoretically alter renal handling.
What this interaction means in plain words
Aspirin rectal and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aspirin has minimal effect on renal prostaglandin-mediated lithium clearance.
What to do
No routine adjustment is needed. Check lithium levels if high-dose salicylate therapy is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Aspirin rectal with Lithium?
MediHelp rates the interaction as minor. Aspirin rectal and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aspirin generally has little effect on serum lithium levels, so a meaningful interaction is unlikely. High doses could theoretically alter renal handling.
How serious is the interaction between Aspirin rectal and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check lithium levels if high-dose salicylate therapy is started.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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