Drug interactions
Aspirin rectal + Olmesartan
Severity: Moderate
Aspirin rectal and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically, so higher doses can reduce olmesartan's antihypertensive effect and affect renal function in vulnerable patients.
What this interaction means in plain words
Aspirin rectal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Systemic aspirin inhibits renal prostaglandin synthesis, reducing renal blood flow and opposing ARB action.
What to do
Monitor blood pressure and creatinine if used at analgesic doses for more than a few days. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Aspirin rectal with Olmesartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically, so higher doses can reduce olmesartan's antihypertensive effect and affect renal function in vulnerable patients.
How serious is the interaction between Aspirin rectal and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and creatinine if used at analgesic doses for more than a few days. Ensure adequate hydration.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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