Drug interactions
Astragalus + Methotrexate
Severity: Minor
Astragalus and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Astragalus has reported immunostimulating properties that may theoretically oppose methotrexate's immunosuppressive effect. The clinical significance is unclear and data are limited.
What this interaction means in plain words
Astragalus and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition from astragalus immune stimulation; not established clinically.
What to do
Review use of herbal products with patients and monitor disease control if astragalus is continued. Consider stopping it if disease activity worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Astragalus with Methotrexate?
MediHelp rates the interaction as minor. Astragalus and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Astragalus has reported immunostimulating properties that may theoretically oppose methotrexate's immunosuppressive effect. The clinical significance is unclear and data are limited.
How serious is the interaction between Astragalus and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review use of herbal products with patients and monitor disease control if astragalus is continued. Consider stopping it if disease activity worsens.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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