Drug interactions
Atenolol + Carbenoxolone
Severity: Moderate
Atenolol and Carbenoxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypertension and hypokalemia, which can oppose atenolol's antihypertensive effect.
What this interaction means in plain words
Atenolol and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing sodium and water retention and potassium loss.
What to do
Monitor blood pressure and serum potassium and consider stopping carbenoxolone or adjusting antihypertensive therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Carbenoxolone?
MediHelp rates the interaction as moderate. Atenolol and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypertension and hypokalemia, which can oppose atenolol's antihypertensive effect.
How serious is the interaction between Atenolol and Carbenoxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium and consider stopping carbenoxolone or adjusting antihypertensive therapy.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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