Drug interactions
Atenolol + Carbidopa-entacapone-levodopa
Severity: Moderate
Atenolol and Carbidopa-entacapone-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and atenolol lowers blood pressure and heart rate. Combined use may produce additive hypotension, particularly at initiation or after dose increases.
What this interaction means in plain words
Atenolol and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Carbidopa-entacapone-levodopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects of dopaminergic stimulation and beta-blockade.
What to do
Monitor supine and standing blood pressure when levodopa is started or adjusted. Lower the atenolol dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as moderate. Atenolol and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and atenolol lowers blood pressure and heart rate. Combined use may produce additive hypotension, particularly at initiation or after dose increases.
How serious is the interaction between Atenolol and Carbidopa-entacapone-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when levodopa is started or adjusted. Lower the atenolol dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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