Drug interactions
Atenolol + Dihydroergotamine intranasal
Severity: Moderate
Atenolol and Dihydroergotamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, and beta-blockade may remove opposing vasodilation. This could add to peripheral vasospasm, although it is uncommon.
What this interaction means in plain words
Atenolol and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasoconstriction from ergot alpha-agonism with loss of beta-2 mediated vasodilation.
What to do
Monitor for cold extremities, numbness, or pain suggesting peripheral ischemia. Stop dihydroergotamine if these signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Dihydroergotamine intranasal?
MediHelp rates the interaction as moderate. Atenolol and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, and beta-blockade may remove opposing vasodilation. This could add to peripheral vasospasm, although it is uncommon.
How serious is the interaction between Atenolol and Dihydroergotamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, numbness, or pain suggesting peripheral ischemia. Stop dihydroergotamine if these signs appear.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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