Drug interactions
Atenolol + Ketorolac
Severity: Moderate
Atenolol and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ketorolac can blunt the blood pressure lowering effect of beta-blockers, especially with prolonged use. Ketorolac may also impair renal function and cause fluid retention, which can further reduce antihypertensive control.
What this interaction means in plain words
Atenolol and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis causes sodium and water retention and opposes antihypertensive effect.
What to do
Monitor blood pressure and renal function if used together beyond a few days. Keep ketorolac courses short and adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Ketorolac?
MediHelp rates the interaction as moderate. Atenolol and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ketorolac can blunt the blood pressure lowering effect of beta-blockers, especially with prolonged use. Ketorolac may also impair renal function and cause fluid retention, which can further reduce antihypertensive control.
How serious is the interaction between Atenolol and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if used together beyond a few days. Keep ketorolac courses short and adjust the antihypertensive regimen if control is lost.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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