Drug interactions
Atenolol + Meclofenamate
Severity: Moderate
Atenolol and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate and other NSAIDs can blunt the antihypertensive effect of atenolol, especially with long-term use. Renal impairment and potassium retention may also occur.
What this interaction means in plain words
Atenolol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis leading to sodium and fluid retention.
What to do
Monitor blood pressure regularly during chronic NSAID use, and check renal function and potassium in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Meclofenamate?
MediHelp rates the interaction as moderate. Atenolol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate and other NSAIDs can blunt the antihypertensive effect of atenolol, especially with long-term use. Renal impairment and potassium retention may also occur.
How serious is the interaction between Atenolol and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly during chronic NSAID use, and check renal function and potassium in at-risk patients.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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