Drug interactions
Atenolol + Olanzapine / samidorphan
Severity: Moderate
Atenolol and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may add to the blood-pressure-lowering effect of atenolol. This can lead to dizziness, falls or syncope, especially at treatment initiation or after dose increases.
What this interaction means in plain words
Atenolol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from olanzapine alpha-1 adrenergic antagonism together with beta-blocker therapy.
What to do
Monitor blood pressure and orthostatic symptoms, especially during olanzapine titration. Lower the atenolol dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Atenolol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may add to the blood-pressure-lowering effect of atenolol. This can lead to dizziness, falls or syncope, especially at treatment initiation or after dose increases.
How serious is the interaction between Atenolol and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during olanzapine titration. Lower the atenolol dose if hypotension develops.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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