Drug interactions
Atenolol + Sacubitril / valsartan
Severity: Moderate
Atenolol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combining them can cause additive hypotension, which is the main concern in heart failure. Beta-blockers are commonly used together with sacubitril/valsartan, but dizziness, renal dysfunction and hyperkalemia need to be watched for.
What this interaction means in plain words
Atenolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects, with a small contribution to hyperkalemia from beta-blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure, heart rate, serum potassium and renal function after initiation and dose changes. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Atenolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combining them can cause additive hypotension, which is the main concern in heart failure. Beta-blockers are commonly used together with sacubitril/valsartan, but dizziness, renal dysfunction and hyperkalemia need to be watched for.
How serious is the interaction between Atenolol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, serum potassium and renal function after initiation and dose changes. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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