Drug interactions
Atenolol + Salsalate
Severity: Minor
Atenolol and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with weak prostaglandin inhibition. It may modestly reduce the antihypertensive effect of atenolol, especially at high doses over a long time.
What this interaction means in plain words
Atenolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of renal prostaglandin synthesis leading to sodium and fluid retention.
What to do
Monitor blood pressure during prolonged salsalate therapy and adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Salsalate?
MediHelp rates the interaction as minor. Atenolol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a non-acetylated salicylate with weak prostaglandin inhibition. It may modestly reduce the antihypertensive effect of atenolol, especially at high doses over a long time.
How serious is the interaction between Atenolol and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged salsalate therapy and adjust the antihypertensive regimen if control is lost.
What other medicines interact with Atenolol?
MediHelp also lists interactions of Atenolol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Atenolol page.
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