Drug interactions
Atenolol + Sildenafil
Severity: Moderate
Atenolol and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil has vasodilating properties and can add to the blood pressure lowering effect of antihypertensives such as atenolol. Symptomatic hypotension is possible, particularly with initiation or higher sildenafil doses.
What this interaction means in plain words
Atenolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive hypotensive effect from PDE5 inhibition-mediated vasodilation and beta-blockade.
What to do
Start sildenafil at a low dose and monitor blood pressure and symptoms of dizziness. Counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Atenolol
- Amifostine + Atenolol Major
- Amiodarone + Atenolol Major
- Atenolol + Atenolol-chlorthalidone Major
- Atenolol + Betaxolol Major
- Atenolol + Bisoprolol Major
- Atenolol + Carvedilol Major
Frequently asked questions
Can I take Atenolol with Sildenafil?
MediHelp rates the interaction as moderate. Atenolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil has vasodilating properties and can add to the blood pressure lowering effect of antihypertensives such as atenolol. Symptomatic hypotension is possible, particularly with initiation or higher sildenafil doses.
How serious is the interaction between Atenolol and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose and monitor blood pressure and symptoms of dizziness. Counsel the patient to rise slowly.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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