Drug interactions
Atenolol-chlorthalidone + Buprenorphine long-acting
Severity: Minor
Atenolol-chlorthalidone and Buprenorphine long-acting: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may stimulate antidiuretic hormone release and reduce the diuretic effect of chlorthalidone. Opioids can also add to hypotension, particularly orthostatic hypotension, when combined with antihypertensives.
What this interaction means in plain words
Atenolol-chlorthalidone and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release may blunt diuresis, and opioid-related vasodilation can add to the antihypertensive effects.
What to do
Monitor blood pressure, fluid status and weight. Adjust the diuretic dose if edema or loss of blood pressure control develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Buprenorphine long-acting?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may stimulate antidiuretic hormone release and reduce the diuretic effect of chlorthalidone. Opioids can also add to hypotension, particularly orthostatic hypotension, when combined with antihypertensives.
How serious is the interaction between Atenolol-chlorthalidone and Buprenorphine long-acting?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and weight. Adjust the diuretic dose if edema or loss of blood pressure control develops.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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