Drug interactions
Atenolol-chlorthalidone + Butabarbital
Severity: Minor
Atenolol-chlorthalidone and Butabarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and lower the levels of many beta blockers. Atenolol is mostly eliminated unchanged by the kidney, so the effect is expected to be small. Additive sedation and hypotension may still occur.
What this interaction means in plain words
Atenolol-chlorthalidone and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction by butabarbital has little effect on renally cleared atenolol, so any reduction is minimal.
What to do
Monitor heart rate and blood pressure when starting or stopping butabarbital. Titrate atenolol to clinical response if control weakens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Butabarbital?
MediHelp rates the interaction as minor. Atenolol-chlorthalidone and Butabarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and lower the levels of many beta blockers. Atenolol is mostly eliminated unchanged by the kidney, so the effect is expected to be small. Additive sedation and hypotension may still occur.
How serious is the interaction between Atenolol-chlorthalidone and Butabarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping butabarbital. Titrate atenolol to clinical response if control weakens.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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