Drug interactions
Atenolol-chlorthalidone + Calcium chloride
Severity: Moderate
Atenolol-chlorthalidone and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium may reduce atenolol absorption, though intravenous calcium chloride would not affect it that way. Chlorthalidone reduces urinary calcium excretion, so large calcium doses can cause hypercalcaemia.
What this interaction means in plain words
Atenolol-chlorthalidone and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium may reduce gastrointestinal absorption of atenolol, and thiazide diuretics increase renal calcium reabsorption.
What to do
Monitor serum calcium and blood pressure, and separate oral calcium from atenolol by at least 2 hours. Use the lowest effective calcium dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Calcium chloride?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium may reduce atenolol absorption, though intravenous calcium chloride would not affect it that way. Chlorthalidone reduces urinary calcium excretion, so large calcium doses can cause hypercalcaemia.
How serious is the interaction between Atenolol-chlorthalidone and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and blood pressure, and separate oral calcium from atenolol by at least 2 hours. Use the lowest effective calcium dose.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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