Drug interactions
Atenolol-chlorthalidone + Calcium citrate
Severity: Moderate
Atenolol-chlorthalidone and Calcium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium supplements may reduce atenolol absorption and weaken its heart rate and blood pressure effects. Chlorthalidone also reduces urinary calcium loss, so hypercalcaemia can develop with high calcium intake.
What this interaction means in plain words
Atenolol-chlorthalidone and Calcium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium may reduce gastrointestinal absorption of atenolol, and thiazide diuretics increase renal calcium reabsorption.
What to do
Separate atenolol and calcium citrate by at least 2 hours. Monitor serum calcium and blood pressure during long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Calcium citrate?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Calcium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium supplements may reduce atenolol absorption and weaken its heart rate and blood pressure effects. Chlorthalidone also reduces urinary calcium loss, so hypercalcaemia can develop with high calcium intake.
How serious is the interaction between Atenolol-chlorthalidone and Calcium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate atenolol and calcium citrate by at least 2 hours. Monitor serum calcium and blood pressure during long-term use.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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