Drug interactions
Atenolol-chlorthalidone + Captopril
Severity: Moderate
Atenolol-chlorthalidone and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril combined with a diuretic and beta-blocker can cause additive hypotension, especially first-dose hypotension in volume-depleted patients. Renal function and potassium may change.
What this interaction means in plain words
Atenolol-chlorthalidone and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Captopril belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with diuretic volume depletion enhancing ACE inhibitor effects on blood pressure and renal perfusion.
What to do
Monitor blood pressure, creatinine and potassium after initiation and dose changes; consider lowering the diuretic dose before starting captopril.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Captopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Captopril?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril combined with a diuretic and beta-blocker can cause additive hypotension, especially first-dose hypotension in volume-depleted patients. Renal function and potassium may change.
How serious is the interaction between Atenolol-chlorthalidone and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after initiation and dose changes; consider lowering the diuretic dose before starting captopril.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
