Drug interactions
Atenolol-chlorthalidone + Cortisone
Severity: Moderate
Atenolol-chlorthalidone and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cortisone has mineralocorticoid activity that increases potassium excretion. Together with chlorthalidone, hypokalemia can be more pronounced, and corticosteroids can also counter the antihypertensive effect.
What this interaction means in plain words
Atenolol-chlorthalidone and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium loss and sodium retention.
What to do
Monitor serum potassium and blood pressure, and give potassium supplementation if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atenolol-chlorthalidone and Cortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Cortisone?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cortisone has mineralocorticoid activity that increases potassium excretion. Together with chlorthalidone, hypokalemia can be more pronounced, and corticosteroids can also counter the antihypertensive effect.
How serious is the interaction between Atenolol-chlorthalidone and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and give potassium supplementation if required.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
