Drug interactions
Atenolol-chlorthalidone + Fenbufen
Severity: Moderate
Atenolol-chlorthalidone and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, can reduce the antihypertensive effect of atenolol and chlorthalidone. NSAIDs combined with diuretics can also increase the risk of renal impairment, especially with dehydration.
What this interaction means in plain words
Atenolol-chlorthalidone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing beta-blocker and diuretic effects.
What to do
Monitor blood pressure and renal function, use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Frequently asked questions
Can I take Atenolol-chlorthalidone with Fenbufen?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, can reduce the antihypertensive effect of atenolol and chlorthalidone. NSAIDs combined with diuretics can also increase the risk of renal impairment, especially with dehydration.
How serious is the interaction between Atenolol-chlorthalidone and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function, use the lowest effective NSAID dose for the shortest time, and ensure adequate hydration.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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