Drug interactions
Atenolol-chlorthalidone + Fenoprofen
Severity: Moderate
Atenolol-chlorthalidone and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can blunt the blood pressure lowering effect of atenolol and chlorthalidone and may promote fluid retention. Concurrent NSAID and diuretic use also increases the risk of renal impairment.
What this interaction means in plain words
Atenolol-chlorthalidone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition leads to sodium retention and reduced renal perfusion.
What to do
Monitor blood pressure and renal function during prolonged use. Choose paracetamol or the shortest NSAID course where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Fenoprofen?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can blunt the blood pressure lowering effect of atenolol and chlorthalidone and may promote fluid retention. Concurrent NSAID and diuretic use also increases the risk of renal impairment.
How serious is the interaction between Atenolol-chlorthalidone and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during prolonged use. Choose paracetamol or the shortest NSAID course where possible.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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