Drug interactions
Atenolol-chlorthalidone + Formoterol
Severity: Moderate
Atenolol-chlorthalidone and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atenolol, though beta-1 selective, can reduce the bronchodilator effect of formoterol and may provoke bronchospasm in susceptible patients. Formoterol and chlorthalidone can both lower potassium, raising arrhythmia risk.
What this interaction means in plain words
Atenolol-chlorthalidone and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta receptors plus additive hypokalemia from beta-2 stimulation and diuretic kaliuresis.
What to do
Monitor respiratory status and serum potassium. Use caution in asthma or COPD and consider alternatives if bronchoconstriction occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Formoterol?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atenolol, though beta-1 selective, can reduce the bronchodilator effect of formoterol and may provoke bronchospasm in susceptible patients. Formoterol and chlorthalidone can both lower potassium, raising arrhythmia risk.
How serious is the interaction between Atenolol-chlorthalidone and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and serum potassium. Use caution in asthma or COPD and consider alternatives if bronchoconstriction occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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